Absence of Interleukin
نویسنده
چکیده
IL-2 represents the dominant growth factor for T lymphocytes, and consequently plays a central role in the development of an immune response (reviewed in reference 1) . Additionally, this cytokine has been implicated in intrathymic T cell development (2, 3) . Severe combined immunodeficiency disease (SCID) t is a rare, heterogeneous, lethal congenital disorder characterized by severe impairment ofT and B cell function, normally associated with T lymphopenia (4) . Although rare forms of this disease have been associated with specific enzyme or receptor deficiencies (5-7), in most cases the defects in lymphocyte development that underlie the immunodeficiency are unknown . In this report we describe an unusual SLID patient with increased T cell numbers and a defect in IL-2 production . The relevance of these findings for present models of T cell development are discussed .
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